Impairing memory consolidation to prevent the development of anticipatory nausea

Conditioned context aversion learning is an important topic for cancer research. After cancer patients have experienced a number of chemotherapy and radiation sessions (US; unconditioned stimuli), the chemotherapy equipment and other physical environmental cues, such as a clock on the wall or interactions with nurses, became conditioned stimuli that trigger anticipatory nausea (AN) as the conditioned response. Thus, preventing the conditioned context aversion that occurs as a result of the formation of the association between the context and the US is one possible strategy for alleviating AN in cancer patients. Our team is developing a novel and innovative approach to prevent the development of a conditioned response by manipulating the memory consolidation of conditioned context aversion learning using amnestic drugs in inbred mice. My laboratory aims to provide novel insights into a recurring problem and ultimately help to develop treatments to alleviate the burden of AN in cancer patients

This project is supported by TÜBİTAK 2232 International Fellowship for Outstanding Researchers Program.